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Clay EFalissard BMoore NToumi M (2013) Contribution of prolonged-release melatonin and anti-benzodiazepine campaigns to the reduction of benzodiazepine and Z-drugs consumption in nine European countries. Yeh AYPressler SJGiordani BJPozehl BJBerger AM (2018) Integrative review abbott laboratories abt the relationship between sleep disturbances and episodic abbott laboratories abt in older adults.

Kramer JHJurik JSha SJRankin KPRosen HJJohnson JKMiller BL (2003) Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Berg L (1988) Clinical Dementia Rating (CDR). Huber RGhilardi MFMassimini MTononi G (2004) Local sleep and learning.

Frase LPiosczyk HZittel SJahn FSelhausen PKrone LFeige BMainberger FMaier JGKuhn MKloppel SNormann Abbott laboratories abtSterr ASpiegelhalder KRiemann DNitsche MANissen C (2016) Modulation of total sleep time by transcranial direct current stimulation (tDCS). Alhola Abbott laboratories abtPolo-Kantola P (2007) Sleep deprivation: Impact on cognitive performance. Cochrane Database Syst Rev 1, CD005593. Song HRWoo YSAbbott laboratories abt HRJun TYBahk WM (2013) Effect of abbott laboratories abt timing of acetylcholinesterase inhibitor ingestion on sleep.

Van Dort CJBaghdoyan HALydic R (2009) Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.

Nofzinger EABuysse DJMiewald JMMeltzer CCPrice JCSembrat RCOmbao HReynolds CFMonk THHall MKupfer Abbott laboratories abtMoore RY (2002) Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking. Lawlor BAAbbott laboratories abt JMartinez RSunderland TMurphy DL (1997) Abbott laboratories abt levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers.

Fabre LFFeighner JP (1983) Long-term therapy for depression with trazodone. Burns MMoskowitz HJaffe J (1986) A abbott laboratories abt of the effects of trazodone and amitriptyline on skills performance by geriatric subjects.

Moskowitz HBurns MM (1986) Cognitive performance in geriatric subjects after acute treatment with antidepressants. Rakel RE (1987) The greater safety of trazodone over tricyclic antidepressant agents: 5-year experience in the United States. Gerner RH (1987) Geriatric depression and treatment with trazodone.

Halliday MRadford HZents KAMMolloy CMoreno JAVerity NCSmith EOrtori CABarrett DABushell MMallucci GR (2017) Abbott laboratories abt drugs targeting eIF2alpha-P-mediated translational repression prevent neurodegeneration in mice. Naidoo NGiang WGalante RJPack AI (2005) Sleep deprivation induces the unfolded protein response in mouse cerebral cortex. Shibboleth log in IOS Press, Inc. Objective: This retrospective study examines whether long-term use of trazodone, an SWS enhancer, is associated with delayed cognitive decline.

Methods: We identified 25 regular trazodone users (mean age 75. Results: Trazodone non-users had 2. Conclusions: These results suggest an association between trazodone use and delayed cognitive decline, adding support for bayer free potentially attractive and cost-effective intervention in dementia.

Data selection on primary and secondary outcomesOur a priori defined primary outcome was the change in MMSE between baseline and final visits. Statistical analysesComparisons on primary and abbott laboratories abt outcomes between the two groups abbott laboratories abt repeated-measures analysis of variance while accounting for inter-evaluation intervals, i.

RESULTSTrazodone longitudinal effects on primary and secondary outcomes are listed in Tables 2 and 3. Join our network: Twitter Facebook LinkedIn RSS feed North America IOS Press, Inc. Get Started Abbott laboratories abt Mendeley and Citeulike bookmarks. However, no studies have been conducted to assess the effect of trazodone on dementia in humans. This electronic health records study assessed the association between trazodone use and the risk of developing dementia in clinical practice.

The Health Improvement Network (THIN), an archive of anonymised medical and prescribing records from primary care practices in abbott laboratories abt United Kingdom, contains records of over 15 million patients. Abbott laboratories abt compared the risk of dementia among patients who were prescribed trazodone to that of patients with similar baseline characteristics prescribed other antidepressants, using a Cox regression model with abbott laboratories abt propensity score matching.

After propensity score matching, 4,596 users of trazadone and 22,980 users of other antidepressants were analysed. The median time to dementia diagnosis for people prescribed trazodone was 1. Incidence of dementia among patients taking trazodone was higher than in matched users of other antidepressants (1. These results suggest that the clinical use of trazodone is not associated with a reduced risk of dementia.

Citation: Brauer R, Lau Abbott laboratories abt, Hayes JF, Man KKC, Osborn DPJ, Howard R, et al. PLoS Med 16(2): e1002728. Data Availability: The data were obtained from the Health Improvement Network (THIN). The codes used to produce the data for this study are provided in the Supporting Information (S1 Table and S2 Table). Funding: The collaboration between the Department of Pharmacology survival Pharmacy of the Abbott laboratories abt of Hong Kong and the UCL School of Pharmacy is funded by The University of Hong Kong-University College London (HKU-UCL) Strategic Partnership Fund.

RB and KKCM are funded by the CW Maplethorpe Fellowship. JFH, Abbott laboratories abt, and RH are supported by the UCLH NIHR Biomedical Research Center. JFH is also abbott laboratories abt by a Wellcome Trust Clinical Research Career Development Fellowship.

DPJO is also in part supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) North Thames at Bart's Health NHS Trust. Competing interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: ICKW has received research funding from Bristol-Myers Squibb, Pfizer, Janssen, the Hong Kong Research Grants Council, and the Hong Kong Health and Medical Research Fund outside the submitted work.

KKCM has received personal fees from IQVIA outside the submitted work. JK is an employee of Valtrex 500 mg film tablet.



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